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Maintenance treatme...
Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy
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- Grövdal, Michael (author)
- Karolinska Institute
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- Karimi, Mohsen (author)
- Karolinska Institutet,Karolinska Institute
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- Khan, Rasheed (author)
- Karolinska Institute
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- Aggerholm, Anni (author)
- Karolinska Institutet,Aarhus University Hospital
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- Antunovic, Petar (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Astermark, Jan (author)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups,Malmö University Hospital
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- Bernell, Per (author)
- Malmö University Hospital
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- Engström, Lena-Maria (author)
- Umeå universitet,Onkologi,University Norrland, Umeå
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- Kjeldsen, Lars (author)
- Rigshospital, Copenhagen
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- Linder, Olle (author)
- Örebro University Hospital
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- Nilsson, Lars (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund University Hospital
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- Olsson, Anna (author)
- Sahlgrens University Hospital
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- Holm, Mette S (author)
- Aarhus University Hospital
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- Tangen, Jon M (author)
- Ullevaal University Hospital
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- Wallvik, Jonas (author)
- Sundsvall Hospital
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- Oberg, Gunnar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Hokland, Peter (author)
- Aarhus University Hospital
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- Jacobsen, Sten Eirik W (author)
- Lund University,Lunds universitet,Karolinska Institutet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Univ Lund Hosp, Haematopoiet Stem Cell Lab, S-22185 Lund, Sweden
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- Porwit, Anna (author)
- Karolinska University Hospital
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- Hellström-Lindberg, Eva (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2010-04-14
- 2010
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 150:3, s. 293-302
- Related links:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- This prospective Phase II study is the first to assess the feasibility and efficacy of maintenance 5-azacytidine for older patients with high-risk myelodysplastic syndrome (MDS), chronic myelomonocytic leukaemia and MDS-acute myeloid leukaemia syndromes in complete remission (CR) after induction chemotherapy. Sixty patients were enrolled and treated by standard induction chemotherapy. Patients that reached CR started maintenance therapy with subcutaneous azacytidine, 5/28 d until relapse. Promoter-methylation status of CDKN2B (P15 ink4b), CDH1 and HIC1 was examined pre-induction, in CR and 6, 12 and 24 months post CR. Twenty-four (40%) patients achieved CR after induction chemotherapy and 23 started maintenance treatment with azacytidine. Median CR duration was 13.5 months, >24 months in 17% of the patients, and 18-30.5 months in the four patients with trisomy 8. CR duration was not associated with CDKN2B methylation status or karyotype. Median overall survival was 20 months. Hypermethylation of CDH1 was significantly associated with low CR rate, early relapse, and short overall survival (P = 0.003). 5-azacytidine treatment, at a dose of 60 mg/m(2) was well tolerated. Grade III-IV thrombocytopenia and neutropenia occurred after 9.5 and 30% of the cycles, respectively, while haemoglobin levels increased during treatment. 5-azacytidine treatment is safe, feasible and may be of benefit in a subset of patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- myelodysplastic syndrome
- azacytidine
- clinical studies
- maintenance therapy
- DNA-methylation
- Haematology
- Hematologi
- therapy
- maintenance
- clinical studies
- myelodysplastic syndrome
- azacytidine
- DNA-methylation
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Grövdal, Michael
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Karimi, Mohsen
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Khan, Rasheed
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Aggerholm, Anni
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Antunovic, Petar
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Astermark, Jan
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show more...
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Bernell, Per
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Engström, Lena-M ...
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Kjeldsen, Lars
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Linder, Olle
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Nilsson, Lars
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Olsson, Anna
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Holm, Mette S
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Tangen, Jon M
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Wallvik, Jonas
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Oberg, Gunnar
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Hokland, Peter
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Jacobsen, Sten E ...
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Porwit, Anna
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Hellström-Lindbe ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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British Journal ...
- By the university
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Umeå University
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Karolinska Institutet
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Lund University
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Linköping University
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Uppsala University